TY  - JOUR
AU  - Nourallah, B.
AU  - Digpal, R.
AU  - Jena, R.
AU  - Watts, C.
PY  - 2017//
TI  - Irradiating the Subventricular Zone in Glioblastoma Patients: Is there a Case for a Clinical Trial?
T2  - Clin Oncol (R Coll Radiol)
JO  - Clinical Oncology (Royal College of Radiologists (Great Britain))
SP  - 26
EP  - 33
VL  - 29
IS  - 1
KW  - Adult
KW  - Brain Neoplasms/*radiotherapy
KW  - Glioblastoma/*radiotherapy
KW  - Humans
KW  - Lateral Ventricles/*radiation effects
KW  - Male
KW  - Neoplastic Stem Cells/radiation effects
KW  - Stem Cell Niche/radiation effects
KW  - Cancer stem cells
KW  - glioblastoma
KW  - neural stem cells
KW  - radiotherapy
KW  - subventricular zone
AB  - Glioblastoma is the most common and aggressive adult brain tumour. Over the last 10 years it has emerged that the subventricular zone (SVZ), the largest adult neural stem cell niche, has an important role in the disease. Converging evidence has implicated transformation of adult neural stems in gliomagenesis and the permissive stem cell niche in disease recurrence. Concurrently, clinical studies have suggested that SVZ involvement is a negative prognostic marker. It would follow that irradiating the SVZ may improve outcomes in glioblastoma by directly targeting this putative sanctuary site. To investigate this potential strategy, 11 retrospective studies and 1 prospective study examined the relationship between dose to the SVZ and survival outcomes in glioblastoma patients. This review summarises the theoretical underpinning of this strategy, provides a critical evaluation of the existing evidence and discusses the rationale for a clinical trial.
SN  - 0936-6555
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27729188
UR  - PM:27729188
N1  - PMID:27729188
ID  - Nourallah_etal2017
ER  -