TY - JOUR AU - Nourallah, B. AU - Digpal, R. AU - Jena, R. AU - Watts, C. PY - 2017// TI - Irradiating the Subventricular Zone in Glioblastoma Patients: Is there a Case for a Clinical Trial? T2 - Clin Oncol (R Coll Radiol) JO - Clinical Oncology (Royal College of Radiologists (Great Britain)) SP - 26 EP - 33 VL - 29 IS - 1 KW - Adult KW - Brain Neoplasms/*radiotherapy KW - Glioblastoma/*radiotherapy KW - Humans KW - Lateral Ventricles/*radiation effects KW - Male KW - Neoplastic Stem Cells/radiation effects KW - Stem Cell Niche/radiation effects KW - Cancer stem cells KW - glioblastoma KW - neural stem cells KW - radiotherapy KW - subventricular zone AB - Glioblastoma is the most common and aggressive adult brain tumour. Over the last 10 years it has emerged that the subventricular zone (SVZ), the largest adult neural stem cell niche, has an important role in the disease. Converging evidence has implicated transformation of adult neural stems in gliomagenesis and the permissive stem cell niche in disease recurrence. Concurrently, clinical studies have suggested that SVZ involvement is a negative prognostic marker. It would follow that irradiating the SVZ may improve outcomes in glioblastoma by directly targeting this putative sanctuary site. To investigate this potential strategy, 11 retrospective studies and 1 prospective study examined the relationship between dose to the SVZ and survival outcomes in glioblastoma patients. This review summarises the theoretical underpinning of this strategy, provides a critical evaluation of the existing evidence and discusses the rationale for a clinical trial. SN - 0936-6555 UR - http://www.ncbi.nlm.nih.gov/pubmed/27729188 UR - PM:27729188 N1 - PMID:27729188 ID - Nourallah_etal2017 ER -