TY  - JOUR
AU  - Labriola, L.
AU  - Pochet, J.-M.
PY  - 2017//
TI  - Any use for alternative lock solutions in the prevention of catheter-related blood stream infections?
T2  - J Vasc Access
JO  - The Journal of Vascular Access
SP  - 34
EP  - 38
VL  - 18
IS  - Suppl. 1
KW  - Anti-Infective Agents/adverse effects/*therapeutic use
KW  - Anticoagulants/therapeutic use
KW  - Bacteremia/diagnosis/microbiology/*prevention &amp
KW  - control
KW  - Biofilms
KW  - Catheter-Related Infections/diagnosis/microbiology/*prevention &amp
KW  - Catheterization
KW  - Central Venous/adverse effects/*instrumentation
KW  - *Catheters
KW  - Indwelling/adverse effects/microbiology
KW  - *Central Venous Catheters/adverse effects/microbiology
KW  - Equipment Design
KW  - Humans
KW  - *Renal Dialysis
KW  - Risk Factors
KW  - Treatment Outcome
AB  - The prevention of catheter-related blood stream infections (CRBSI) in hemodialysis (HD) patients remains a challenge because of high morbidity and mortality associated to CRBSI. Alternative locking solutions (ALS) containing an antithrombotic substance with additional antimicrobial or antibiofilm properties (citrate, ethylenediaminetetraacetic acid [EDTA], 70% ethanol, thrombolytics) with or without the addition of molecules with specific antimicrobial activity (antibiotics, taurolidine, paraben-methylene-blue) has been proposed with the aim to prevent or eradicate intraluminal biofilm colonization and subsequent CRBSI. In this review, we examine the available evidence concerning their efficacy and potential side effects, in order to determine whether ALS should be implemented widely or only in selected cases.
SN  - 1129-7298
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28297055
UR  - PM:28297055
N1  - PMID:28297055
ID  - Labriola+Pochet2017
ER  -