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Kaufman, D. (2016). Umbilical catheter removal and bloodstream infections: 'A case of too many antibiotics'. Acta Paediatr, 105(4), 343–345.
Keywords: Anti-Bacterial Agents/*therapeutic use; Bacteremia/drug therapy; Catheter-Related Infections; *Catheterization, Central Venous; Humans; Vascular Access Devices
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Lindquist, S., Hentz, E., Tessin, I., & Elfvin, A. (2016). Very low birthweight infants face an increased risk of bloodstream infections following the removal of umbilical catheters. Acta Paediatr, 105(4), 391–396.
Abstract: AIM: This study examined whether there was a temporal association between removing umbilical catheters and bloodstream infections (BSI) in a neonatal intensive care unit, as this is an area of research that has not received sufficient attention. METHODS: We carried out a retrospective study of all neonates receiving umbilical catheters during 2011 and 2012 in the neonatal intensive care unit at Sahlgrenska University Hospital, Gothenburg, Sweden. The time from umbilical catheter removals to the first subsequent BSI was recorded. RESULTS: A total of 372 infants had umbilical catheters inserted and 146 of these had a birthweight of <1500 g. Antibiotics were discontinued when umbilical catheters were removed in 67 of these low birthweight infants and 20 of them needed to be retreated for BSI within 72 hours. We found that very low birthweight infants had a significantly increased risk of developing BSI if antibiotics were discontinued at the same time as umbilical catheters were removed, rather than being continued after removal (p < 0.001). CONCLUSION: This NICU study demonstrated a temporal association between removing umbilical catheters and BSI in very low birthweight infants weighting <1500 g.
Keywords: Bacteremia/*etiology; Catheters/*adverse effects; Humans; Infant, Newborn; Infant, Very Low Birth Weight; Retrospective Studies; Umbilicus/surgery; Central venous catheter; Low birthweight infants; Neonatal septicaemia; Preterm infant; Umbilical artery catheter
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Kaufman, D. (2016). Umbilical catheter removal and bloodstream infections: 'A case of too many antibiotics'. Acta Paediatr, 105(4), 343–345.
Keywords: Anti-Bacterial Agents/*therapeutic use; Bacteremia/drug therapy; Catheter-Related Infections; *Catheterization, Central Venous; Humans; Vascular Access Devices
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Lindquist, S., Hentz, E., Tessin, I., & Elfvin, A. (2016). Very low birthweight infants face an increased risk of bloodstream infections following the removal of umbilical catheters. Acta Paediatr, 105(4), 391–396.
Abstract: AIM: This study examined whether there was a temporal association between removing umbilical catheters and bloodstream infections (BSI) in a neonatal intensive care unit, as this is an area of research that has not received sufficient attention. METHODS: We carried out a retrospective study of all neonates receiving umbilical catheters during 2011 and 2012 in the neonatal intensive care unit at Sahlgrenska University Hospital, Gothenburg, Sweden. The time from umbilical catheter removals to the first subsequent BSI was recorded. RESULTS: A total of 372 infants had umbilical catheters inserted and 146 of these had a birthweight of <1500 g. Antibiotics were discontinued when umbilical catheters were removed in 67 of these low birthweight infants and 20 of them needed to be retreated for BSI within 72 hours. We found that very low birthweight infants had a significantly increased risk of developing BSI if antibiotics were discontinued at the same time as umbilical catheters were removed, rather than being continued after removal (p < 0.001). CONCLUSION: This NICU study demonstrated a temporal association between removing umbilical catheters and BSI in very low birthweight infants weighting <1500 g.
Keywords: Bacteremia/*etiology; Catheters/*adverse effects; Humans; Infant, Newborn; Infant, Very Low Birth Weight; Retrospective Studies; Umbilicus/surgery; Central venous catheter; Low birthweight infants; Neonatal septicaemia; Preterm infant; Umbilical artery catheter
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Burbulla, L. F., Beaumont, K. G., Mrksich, M., & Krainc, D. (2016). Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks. Adv Healthc Mater, 5(15), 1894–1903.
Abstract: The discovery of induced pluripotent stem cells (iPSCs) and their application to patient-specific disease models offers new opportunities for studying the pathophysiology of neurological disorders. However, current methods for culturing iPSC-derived neuronal cells result in clustering of neurons, which precludes the analysis of individual neurons and defined neuronal networks. To address this challenge, cultures of human neurons on micropatterned surfaces are developed that promote neuronal survival over extended periods of time. This approach facilitates studies of neuronal development, cellular trafficking, and related mechanisms that require assessment of individual neurons and specific network connections. Importantly, micropatterns support the long-term stability of cultured neurons, which enables time-dependent analysis of cellular processes in living neurons. The approach described in this paper allows mechanistic studies of human neurons, both in terms of normal neuronal development and function, as well as time-dependent pathological processes, and provides a platform for testing of new therapeutics in neuropsychiatric disorders.
Keywords: aging; human induced pluripotent stem cells; long-term neuronal culture; microcontact printing technology; neurodegenerative disorders
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