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Requia, W. J., Koutrakis, P., Roig, H. L., Adams, M. D., & Santos, C. M. (2016). Association between vehicular emissions and cardiorespiratory disease risk in Brazil and its variation by spatial clustering of socio-economic factors. Environ Res, 150, 452–460.
Abstract: Many studies have suggested that socio-economic factors are strong modifiers of human vulnerability to air pollution effects. Most of these studies were performed in developed countries, specifically in the US and Europe. Only a few studies have been performed in developing countries, and analyzed small regions (city level) with no spatial disaggregation. The aim of this study was to assess the association between vehicle emissions and cardiorespiratory disease risk in Brazil and its modification by spatial clustering of socio-economic conditions. We used a quantile regression model to estimate the risk and a geostatistical approach (K means) to execute spatial cluster analysis. We performed the risk analysis in three stages. First, we analyzed the entire study area (primary analysis), and then we conducted a spatial cluster analysis based on various municipal-level socio-economic factors, followed by a sensitivity analysis. We studied 5444 municipalities in Brazil between 2008 and 2012. Our findings showed a significant association between cardiorespiratory disease risk and vehicular emissions. We found that a 15% increase in air pollution is associated with a 6% increase in hospital admissions rates. The results from the spatial cluster analysis revealed two groups of municipalities with distinct sets of socio-economic factors and risk levels of cardiorespiratory disease related to exposure to vehicular emissions. For example, for vehicle emissions of PM in 2008, we found a relative risk of 4.18 (95% CI: 3.66, 4.93) in the primary analysis; in Group 1, the risk was 0.98 (95% CI: 0.10, 2.05) while in Group 2, the risk was 5.56 (95% CI: 4.46, 6.25). The risk in Group 2 was 480% higher than the risk in Group 1, and 35% higher than the risk in the primary analysis. Group 1 had higher values (3rd quartile) for urbanization rate, highway density, and GDP; very high values (>/=3rd quartile) for population density; median values for distance from the capital; and lower values (1st quartile) for rural population density. Group 2 had lower values (1st quartile) urbanization rate; median values for highway density, GDP, and population density; between median and third quartile values for distance from the capital; and higher values (3rd quartile) for rural population density. Our findings suggest that socio-economic factors are important modifiers of the human risk of cardiorespiratory disease due to exposure to vehicle emissions in Brazil. Our study provides support for creating effective public policies related to environmental health that are targeted to high-risk populations.
Keywords: Air Pollutants/*analysis; Brazil/epidemiology; Carbon Monoxide/analysis; Cardiovascular Diseases/*epidemiology; Cluster Analysis; Environmental Monitoring; Hospitalization/statistics & numerical data; Humans; Hydrocarbons/analysis; Methane/analysis; Nitrogen Oxides/analysis; Particulate Matter/analysis; Respiratory Tract Diseases/*epidemiology; Risk; Socioeconomic Factors; Vehicle Emissions/*analysis; Air pollution; Cardiorespiratory disease; Human health; Spatial cluster analysis; Vehicle emissions
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Mpofu, J. J., de Moura, L., Farr, S. L., Malta, D. C., Iser, B. M., Ivata Bernal, R. T., et al. (2016). Associations between noncommunicable disease risk factors, race, education, and health insurance status among women of reproductive age in Brazil – 2011. Prev Med Rep, 3, 333–337.
Abstract: BACKGROUND: Noncommunicable disease (NCD) risk factors increase the risk of adverse reproductive health outcomes and are becoming increasingly common in Brazil. METHODS: We analyzed VIGITEL 2011 telephone survey data for 13,745 Brazilian women aged 18-44 years in a probabilistic sample from 26 Brazilian state capitals and the Federal District. We examined associations between NCD risk factors (fruit and vegetable intake, leisure time physical activity, alcohol consumption, smoking status, BMI and hypertension status) and race, education, and insurance using chi-square tests and multivariable logistic regression models, estimating the average marginal effects to produce adjusted relative risk ratios (aRRs). Analyses were conducted using SAS 9.3 survey procedures and weighted to reflect population estimates. RESULTS: Women with less than a college education were more likely to report physical inactivity (adjusted relative risk (aRR) and 95% confidence interval = 1.1 (1.1-1.2)), smoking (aRR = 1.7 (1.3-2.2)), and self-reported diagnoses of hypertension (aRR = 2.0 (1.6-2.5)) compared to women with a college education or greater. Similarly, women without health insurance were more likely to report physical inactivity (aRR = 1.1 (1.1-1.2)), smoking (aRR = 1.4 (1.1-1.8)), and self-reported diagnoses of hypertension aRR = 1.4 (1.1-1.7)) compared to women with health insurance. Less variation was found by race and NCD risk factors. CONCLUSION: Targeted public health strategies and policies are needed to increase healthcare access and decrease educational and racial disparities in NCD risk factors among women of reproductive age in Brazil.
Keywords: Chronic disease; Education; Health; Insurance; Reproductive health; Risk factors; Women
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Kissane-Lee, N. A., Yule, S., Pozner, C. N., & Smink, D. S. (2016). Attending Surgeons' Leadership Style in the Operating Room: Comparing Junior Residents' Experiences and Preferences. J Surg Educ, 73(1), 40–44.
Abstract: PURPOSE: Recent studies have focused on surgeons' nontechnical skills in the operating room (OR), especially leadership. In an attempt to identify trainee preferences, we explored junior residents' opinions about the OR leadership style of teaching faculty. METHODS: Overall, 20 interns and 20 mid-level residents completed a previously validated survey on the style of leadership they encountered, the style they preferred to receive, and the style they personally employed in the OR. In all, 4 styles were explored; authoritative: leader makes decisions and communicates them firmly; explanatory: leader makes decisions promptly, but explains them fully; consultative: leader consults with trainees when important decisions are made, and delegative: leader puts the problem before the group and makes decisions by majority opinion. Comparisons were completed using chi-square analysis. RESULTS: Junior resident preference for leadership style of attending surgeons in the OR differed from what they encountered. Overall, 62% of residents encountered an authoritative leadership style; however, only 9% preferred this (p < 0.001). Instead, residents preferred explanatory (53%) or consultative styles (41%). Preferences differed by postgraduate year. Although 40% of interns preferred a consultative style, 50% of mid-level residents preferred explanatory leadership. CONCLUSIONS: Junior resident preference of leadership style in the OR differs from what they actually encounter. This has the potential to create unwanted tension and may erode team performance. Awareness of this difference provides an opportunity for an educational intervention directed at both attendings and trainees.
Keywords: Adult; *Attitude of Health Personnel; *Faculty, Medical; Female; Humans; *Internship and Residency; *Leadership; Male; Medical Staff, Hospital; *Operating Rooms; Specialties, Surgical/*education; Interpersonal and Communication Skills; Practice-Based Learning and Improvement; Professionalism; leadership in the operating room; surgical resident education; surgical simulation
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Yi, F., Danko, T., Botelho, S. C., Patzke, C., Pak, C. H., Wernig, M., et al. (2016). Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science, 352(6286), aaf2669.
Abstract: Heterozygous SHANK3 mutations are associated with idiopathic autism and Phelan-McDermid syndrome. SHANK3 is a ubiquitously expressed scaffolding protein that is enriched in postsynaptic excitatory synapses. Here, we used engineered conditional mutations in human neurons and found that heterozygous and homozygous SHANK3 mutations severely and specifically impaired hyperpolarization-activated cation (Ih) channels. SHANK3 mutations caused alterations in neuronal morphology and synaptic connectivity; chronic pharmacological blockage of Ih channels reproduced these phenotypes, suggesting that they may be secondary to Ih-channel impairment. Moreover, mouse Shank3-deficient neurons also exhibited severe decreases in Ih currents. SHANK3 protein interacted with hyperpolarization-activated cyclic nucleotide-gated channel proteins (HCN proteins) that form Ih channels, indicating that SHANK3 functions to organize HCN channels. Our data suggest that SHANK3 mutations predispose to autism, at least partially, by inducing an Ih channelopathy that may be amenable to pharmacological intervention.
Keywords: Action Potentials; Animals; Autism Spectrum Disorder/*genetics; Cells, Cultured; Channelopathies/*genetics; Chromosome Deletion; Chromosome Disorders/genetics; Chromosomes, Human, Pair 22/genetics; Embryonic Stem Cells/metabolism; Gene Deletion; Genetic Engineering; *Genetic Predisposition to Disease; Haploinsufficiency/*genetics; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism; Mice; Mice, Knockout; Mutagenesis; Nerve Tissue Proteins/*genetics/metabolism; Neurons/*metabolism; Synapses/physiology; Synaptic Transmission
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Boim, A. G. F., Melo, L. C. A., Moreno, F. N., & Alleoni, L. R. F. (2016). Bioconcentration factors and the risk concentrations of potentially toxic elements in garden soils. J Environ Manage, 170, 21–27.
Abstract: Empirical models describe soil-plant transfers to explain the variations in the occurrence of potentially toxic elements (PTE) in soils and to estimate the Bioconcentration Factor (BCF). In this study, results were selected based on data in the literature on soils of humid tropical and temperate regions to evaluate soil-plant transfer models, to calculate the BCF and to derive risk concentrations of Cu, Cr, Pb, Ni and Zn present in the exposure pathway leading to the consumption of contaminated vegetables. The Cetesb (Environmental Agency of the State of Sao Paulo, Brazil) mathematical model was used to derive the risk posed by soil concentrations in urban and rural exposure scenarios. The results of the pseudo total contents of PTE in the soil and the contents absorbed by plants were compared and the BCFs were calculated by the use of geometric means, including a correction factor appropriate to each particular type of soil. Differences were observed between BCFs calculated for each climate region: humid tropical (HTR) and temperate (TE), which the first one presented the highest values to BCF in leaves and the lowest BCF values for root, except Ni, compared to second one. The soil concentrations with the highest risk were found in humid tropical regions as compared with those found in temperate regions, except for Ni. The obtained BCFs may contribute to any future revisions of guideline values as well as help other state environmental agencies to establish their own guideline values.
Keywords: Brazil; Environmental Monitoring; Food Contamination/*prevention & control; Humans; Humidity; Metals, Heavy/chemistry/*metabolism; Policy; Risk Assessment; Soil/*chemistry; Soil Pollutants/chemistry/*metabolism; Tropical Climate; Vegetables/*metabolism; Cetesb; Environmental management; Guideline values; Human health risk; Soil policies
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